Vanquish

Thermo Scientific™ Vanquish™ is a high-performance, modular platform for HPLC and UHPLC analysis, designed to provide reliability, precision, and flexibility – from routine laboratory analysis to the most demanding UHPLC applications.

Thermo Scientific™ Vanquish™ HPLC and UHPLC systems provide a comprehensive platform for modern liquid chromatography, combining high performance, precise flow and temperature control, reliable sample introduction, and a broad choice of detection technologies.

The modular architecture enables each system to be configured according to specific analytical requirements and adapted to a wide range of applications – from routine quality control and transfer of existing HPLC methods to method development, high-efficiency UHPLC separations, and LC-MS analysis.

The Vanquish platform includes several systems optimized for different analytical requirements. Vanquish Core HPLC is designed for dependable, high-productivity routine analysis, Vanquish Flex UHPLC provides increased flexibility for HPLC and UHPLC applications and method development, while Vanquish Horizon UHPLC delivers maximum performance for high-efficiency and high-resolution separations. Specialized Vanquish Duo configurations employ two independent flow paths to increase productivity and extend analytical capabilities.

Intelligent system design, reliable fluidic connections, and integration with Chromeleon™ Chromatography Data System (CDS) support workflow automation, straightforward method transfer, and reproducible analytical results.

Vanquish – one platform offering different levels of performance and flexibility for modern HPLC and UHPLC laboratories.

		Vanquish Horizon UHPLC	Vanquish Flex UHPLC	Vanquish Core HPLC
		Unrivaled performance and throughput for applications requiring high-end UHPLC	Binary or quaternary solvent blending for fast and reliable UHPLC or flexible method development	Remove any disruptions from your routine HPLC analyses
Performance	System pressure	Up to 1500 bar	Up to 1000 bar	Up to 700 bar
	Retention time precision
	Flow range	5 mL/min	8 mL/min	10 mL/min
	Biocompatibility	Yes	Yes	N/A
	Design	Modular
System components	Pump	Vanquish Binary Pump H The pump with the highest backpressure at 1500 bar, and ideal for any gradient performance from shallow to ballistic	Vanquish Binary Pump F UHPLC performance for demanding routine applications up to 1000 bar Vanquish Quaternary Pump F UHPLC performance with more solvent flexibility up to 1000 bar	Vanquish Binary Pump C Simplicity and throughput for routine HPLC applications up to 700 bar Vanquish Quaternary Pump C Flexibility and dependability for routine HPLC applications up to 700 bar Vanquish Isocratic Pump C Simplicity for basic HPLC applications up to 700 bar
	Autosampler	Vanquish Split Sampler HT Excellent precision, accuracy, and short cycle times with innovative air-stream cooling and barcode reading for inventory management for all workflows up to 1500 bar	Vanquish Split Sampler FT Enjoy the same benefits as the Vanquish Split Sampler HT for applications up to 1000 bar	Vanquish Dual Split Sampler C/CT Delivering extreme dependability and reliability for routine HPLC applications up to 700 bar. Optional thermostatting for samples.
	Extended sample capacity	Vanquish Charger An intelligent, robotic rack and plate feeder that automatically loads samples in the autosampler and extends the sample capacity of all Vanquish samplers to up to 8832 samples (23 wellplates or 12 vial racks) with innovative air-stream cooling and barcode reading for inventory management
	Column compartment	Vanquish Column Compartment H Provides two column thermostatting modes (still and forced air), active and passive solvent pre-heating, and post-column cooling for optimized control of your separations and advanced method transfer. Temperature range: 5–120 °C		Vanquish Column Compartment C High performance and flexibility in thermostatting mode to simplify method transfer from any HPLC system. Temperature range: 5–85 °C
	Virtually zero dead volume system connections	Viper UHPLC Fittings Kits Order all the UHPLC fittings and capillaries you need for your system or application in a single kit

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Vanquish Core HPLC

Thermo Scientific™ Vanquish™ Core HPLC is a reliable and flexible HPLC system designed for routine analysis, quality control, and transfer of established methods. With operating pressures up to 700 bar, high precision, and a modular architecture, Vanquish Core delivers excellent reproducibility and consistent performance for the everyday needs of the modern analytical laboratory.

Vanquish Horizon UHPLC

Thermo Scientific™ Vanquish™ Horizon UHPLC is a high-performance UHPLC system designed for the most demanding chromatographic separations. With operating pressures up to 1500 bar, high precision, and minimal system volume, Vanquish Horizon delivers excellent resolution, sensitivity, and reproducibility for fast, high-efficiency UHPLC and LC-MS analyses.

Vanquish Flex UHPLC

Thermo Scientific™ Vanquish™ Flex UHPLC is a flexible, high-performance UHPLC system designed for a broad range of analytical applications and method development. With operating pressures up to 1000 bar, a modular configuration, and a wide choice of detection technologies, Vanquish Flex provides excellent reproducibility and easy adaptation to diverse HPLC and UHPLC workflows.

Vanquish Duo UHPLC

Thermo Scientific™ Vanquish™ Duo UHPLC is an innovative dual-flow platform designed to increase the productivity and efficiency of LC analyses. Flexible Duo configurations enable parallel analysis, tandem LC, and other advanced workflows, reducing analysis time and increasing laboratory throughput.

Vanquish Access HPLC

Thermo Scientific™ Vanquish™ Access HPLC is a reliable and easy-to-operate HPLC system designed for routine analysis in laboratories where reproducibility, stable performance, and efficiency are key priorities.