​Low-Flow LC

Low-flow liquid chromatography encompasses nano-, capillary-, and micro-flow LC technologies designed for highly sensitive analyses at significantly lower flow rates than conventional analytical HPLC and UHPLC. These approaches are particularly well suited for LC-MS applications where sample amounts are limited or maximum sensitivity is required.

Operating at lower flow rates reduces analyte dilution and can significantly enhance sensitivity in LC-MS analysis. Depending on application requirements, different flow regimes can be employed – nano-flow for maximum sensitivity and sample-limited analysis, capillary-flow for an optimal balance between sensitivity and throughput, and micro-flow for increased robustness and higher sample throughput.

Low-flow LC is widely used in proteomics, biopharmaceutical research, peptide and protein analysis, biomarker research, and other high-sensitivity LC-MS applications.

The Thermo Scientific™ Vanquish™ Neo UHPLC is a dedicated platform for nano-, capillary-, and micro-flow liquid chromatography. The system covers a broad low-flow range and operates at pressures up to 1500 bar, providing high flow precision and reproducible retention times. Combined with dedicated low-flow columns, capillary connections, and Thermo Scientific mass spectrometry systems, Vanquish Neo provides a comprehensive solution for modern high-sensitivity LC-MS workflows.

Vanquish Neo UHPLC System

Thermo Scientific™ Vanquish™ Neo UHPLC is a high-performance system for nano-, capillary-, and micro-flow liquid chromatography, designed for highly sensitive LC-MS analysis. With a broad flow-rate range and operating pressures up to 1500 bar, Vanquish Neo delivers the precision, reproducibility, and flexibility required for modern proteomics and biopharmaceutical applications.