Stellar Mass Spectrometer

Thermo Scientific™ Stellar™ Mass Spectrometer expands targeted quantitative capabilities by combining quadrupole precursor selection with a hyper-fast dual-pressure linear ion trap. The system supports studies requiring the measurement of multiple analytes, high sensitivity, and additional structural information.

The QR5 Plus quadrupole mass filter selects precursor ions, while the Ion Concentrating Routing Multipole (ICRM) provides ion accumulation and HCD fragmentation. Synchronized ion packet management enables the next ion population to accumulate while the preceding packet is analyzed in the linear ion trap, improving ion utilization.

Targeted MS² and MS³ acquisition, using CID and HCD fragmentation, provides additional selectivity for complex biological matrices. Full product-ion spectra support quantitation and differentiation of compounds for which conventional MS/MS analysis may not provide sufficient specificity.

The OptaMax™ Plus ion source improves desolvation and ionization at analytical LC flow rates. The integrated Auto-Ready™ ion source enables scheduled or on-demand automated calibration without reconfiguring the LC-MS connection.

The PRM Conductor software tool, used with Skyline, supports multiplexed targeted method development from previously acquired spectral data. Adaptive RT adjusts acquisition windows in real time to accommodate retention-time shifts. Instrument operation integrates with the Xcalibur™ software environment.

Stellar supports targeted proteomics, metabolomics, lipidomics, small-molecule analysis, and biomarker research. Applications range from quantitative analysis of metabolites and drug metabolites to peptide and protein measurements.

Transition biomarker candidates from discovery to validation more efficiently, confidently, and at lower cost with the Thermo Scientific™ Stellar™ mass spectrometer. With breakthroughs in sensitivity, specificity, and throughput at scale, you can verify more putative biomarkers in less time and with less effort. Revolutionary technology delivers rapid full scan MSn acquisition with single ion sensitivity improving limits of quantitation (LOQ) 10x when targeting 5x more analytes. Novel software automates multi-analyte method creation, dynamic instrument control for unmatched productivity.

The Stellar mass spectrometer drives biomarker discovery to validation at unprecedented scale by combining advanced quadrupole technology and the Hyper-fast Dual Pressure Linear ion trap mass analyzer acquiring sensitive and reproducible data at speeds up to 140 Hz. The PRM Conductor software leverages discovery data to rapidly and confidently build highly multiplexed targeted quantitative methods as well as manage data acquisition to further increase laboratory productivity and capacity by almost 80% compared to existing workflows. Primary benefits of the Stellar MS include:

• Expanded scale
• Higher sensitivity
• Greater specificity
• Massive throughput
• Unrivaled productivity

For Use With (Application):
Pharmaceutical
Clinical Research
Forensic Toxicology
Proteomics
Metabolomics
Biopharmaceutical